Specialized Equipment and Services

The BOND RXm is an automated staining system that increases reproducibility of IHC (chromogenic or immunofluorescent) and multiplex staining.

Researchers can design their ideal protocol with customization options across all protocol editing segments. The system is fully automated and provides unmatched protocol. Flexibility and fully open reagents, allowing researchers to retain complete control of their staining.

Features of the BOND RX include:

• Users could directly edit the temperature of any step (reagent or wash step) in ISH and IHC staining protocols, single or sequential double staining protocols and parallel double staining protocols
• Eliminate manual or semi-automated staining
• Protocol flexibility and choice of reagents
• Fully automated IHC, ISH and emerging tests
• Reduce process variability with full automation
• Protect tissue with the unique Covertile system

The Autostainer Link 48 ensures optimal staining results and offers a high slide and reagent capacity. It delivers high-quality staining, maximum versatility, and high productivity.

Features of the Autostainer Link 48 include:

• Instrument precision and stability
• Optimized reagents and protocols
• Flexible run options
• Process 48 slides in less than three hours
• Process slides in parallel using PT Link

The Aperio VERSA is a comprehensive digital pathology scanner, designed and developed to support the diverse imaging needs of cutting-edge research facilities. The combination scanner is optimized for precision scanning of brightfield and fluorescent samples, with the accuracy and resolution required for FISH.

From tissue-based and proteomic markers, to subcellular, molecular, and in-situ hybridization probes, the Aperio VERSA delivers high-resolution, reliable imaging. 

The Aperio VERSA is ideal for scanning multiplex slides at any magnification from 5x to 40x for the whole slide without the need for spectral imaging. It delivers excellence in IHC, ISH and Fluorescent Tissue-Based Research including multiplex whole slide scanning.

Features of the Aperio VERSA include:

• Advanced tissue detection for faint for lightly stained brightfield and fluorescent samples
• Scan slides from 0.9mm to 1.2mm thick
• Z-stack capture for thick samples
• 2-D scanning technology, ideal for co-localization studies
• Broad range of compatible image analysis solutions
• Scan 15mmx15mm @20x brightfield in 206 seconds

The Aperio VERSA has the following filters:

1. Blue: emission filters: 460/50m, excitation filters: 360/50x
2. Green: emission filters: 537/29m, excitation filters: 495/25x
3. Orange: emission filters:572/23m, excitation filters: 546/10x
4. Red: emission filters of 625/30m, excitation filters: 580/25x

Introducing our newest powerhouse in digital pathology research: The Precision 5820 Tower. Equipped with cutting-edge technology, this machine features an Intel Xeon Processor W-2295 with 18 cores operating up to 4.6GHz Turbo, supported by 256GB DDR4 ECC Memory, and a robust Nvidia RTX A5000 graphics card with 24GB of memory. Its extensive storage capabilities include a 4TB M.2 NVMe Class 40 Solid State Drive and a massive 20 TB Seagate IronWolf Pro internal hard drive.

To complement this advanced hardware, the system boasts a suite of specialized software tailored for machine learning in digital pathology:

QuPath

An open-source software tool for digital pathology image analysis. It offers powerful annotation and analysis capabilities, helping pathologists and researchers efficiently manage whole-slide images.

CellProfile

A versatile image analysis program that quantifies cell phenotypes from thousands of images automatically, facilitating high-throughput image analysis with precision.

Ilastik

A user-friendly software that enables classification, segmentation, and analysis of biomedical images, making machine learning techniques accessible without requiring extensive programming knowledge.

Orbit

An advanced image analysis tool designed for use in digital pathology. It handles massive whole-slide images and integrates seamlessly with machine learning models to provide robust tissue analysis.

Cytomine

An open-source web platform that allows collaborative analysis of enormous bioimaging data, enhancing research productivity and data-sharing capabilities.

PathML

A novel framework for machine learning in pathology. It streamlines the development of computational pathology pipelines, enabling researchers to focus more on research questions rather than technical intricacies.

This system not only accelerates the processing and analysis of large-scale digital pathology data but also supports the development of new diagnostic tools and therapeutic strategies. With such capabilities, our research team is set to redefine the possibilities in pathology and disease diagnosis.

The Hitachi HT7800 Bio-TEM 120 kV transmission electron microscope and is designed for superior biological imaging.

The HT7800 has many convenient features to aid in image acquisition, including:

• A dual-mode objective lens that supports easy observation under low magnification, wide-field high contrast and high resolution.
• Advanced stage-navigation function that enables whole-grid searching and efficient image acquisition. Motorized Z stage.
• Automated image stitching, 3D tomography, automated multi-frame panoramic function, drift correction, auto pre-irradiation, pneumatic objective apertures and electron beam tomography.
• Single and three specimen holders.
• AMT NanoSprint43 MkII 43mp CMOS camera.